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KMID : 1188320160100020212
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Gut and Liver
2016 Volume.10 No. 2 p.212 ~ p.219
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Comparison between Resectable Helicobacter pylori-Negative and -Positive Gastric Cancers
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Kim Hee-Jin
Kim Na-Young
Yoon Hyuk
Choi Yoon-Jin
Lee Ju-Yup
Kwon Yong-Hwan
Yoon Ki-Chul
Jo Hyun-Jin
Shin Cheol-Min
Park Young-Soo
Park Do-Joong
Kim Hyung-Ho
Lee Hye-Seung
Lee Dong-Ho
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Abstract
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Background/Aims:Controversy exists regarding the characteristics of Helicobacter pylori infection-negative gastric cancer (HPIN-GC). The aim of this study was to evaluate clinicopathologic features of HPIN-GC compared to H. pylori infection-positive gastric cancer (HPIP-GC) using a comprehensive analysis that included genetic and environmental factors.
Methods:H. pylori infection status of 705 resectable gastric cancer patients was determined by the rapid urease test, testing for anti-H. pylori antibodies, histologic analysis and culture of gastric cancer tissue samples, and history of H. pylori eradication. HPIN-GC was defined as gastric cancer that was negative for H. pylori infection based on all five methods and that had no evidence of atrophy in histology or serology.
Results:The prevalence of HPIN-GC was 4% (28/705). No significant differences with respect to age, sex, smoking, drinking, family history of gastric cancer or obesity were observed between the two groups. HPIN-GC tumors were marginally more likely to involve the cardia (14.3% for HPIN-GC vs 5.3% for HPIP-GC, p=0.068). The Lauren classification, histology, and TNM stage did not differ according to H. pylori infection status. Microsatellite instability was not different between the two groups, but p53 overexpression in HPIN-GC was marginally higher than in HPIP-GC (56.0% for HPIN-GC vs 37.0% for HPIP-GC, p=0.055).
Conclusions:The prevalence of HPIN-GC was extremely low, and its clinicopathologic characteristics were similar to HPIP-GC.
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KEYWORD
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Helicobacter pylori, Stomach neoplasms, Negative infection, Atrophy
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